The driver type. On Windows you should choose ASIO (on macOS it's CoreAudio by default)
The sound card that is used to output the sound
The output channel if your audio interface has multple outputs
The samplerate that HISE uses for rendering the audio. Make sure that this matches the sample rate on your audio interface, or you will get artifacts.
The buffer size in samples that will be used to render the audio. The best numbers are power-of two numbers, which should be preffered if possible.
The MIDI input device list. It should get updated automatically if you connect a new MIDI device - if not try restarting HISE
A list of all MIDI channels that should be processed. By default all channels are processed, but you might want to filter out some channels depending on your setup.